Job Opening: Assistant Project Scientist
Tobacco Related-Disease Research Program
- New Recruitment: Assistant Project Scientist - Tobacco Related-Disease Research Program for the Air Quality Research Center
Assistant Project Scientist - Tobacco Related-Disease Research Program
Air Quality Research Center
This position requires creative contribution to and collaborative development of an active research program focused on the health effects of inhaled air pollutants, especially nicotine delivery products such as cigarettes, cigars, and vapes. The incumbent will be involved in planning and execution of laboratory experiments and associated modeling studies. The incumbent will also collaborate with other researchers and laboratory co-workers. Research activities will include interaction and collaboration with on- and off-campus researchers. The incumbent will communicate the results of these activities to the respective funding agencies.
- Measuring Smoke Deposition and Retention in Airways. The first stage in the development of health effects from inhaled smoke is deposition and retention of the smoke in the airways, and then retention of this smoke for a sufficiently long time that it elicits health effects. This work primarily involves working with laboratory animals, usually rats, to expose them to the smoke, measure the deposition in the airways, and also measure the rate of clearance of the deposited particles from the airways or the amount retained as a function of time. The gases and the particles deposit at different rates and are likely also cleared at different rates. Likewise, particle clearance is a function of particle size and chemical composition. The incumbent will generate smoke environments, expose laboratory animals to these environments, and measure deposition and retention of the smoke constituents.
- Modeling Smoke Deposition and Retention in Airways. Although measurements of smoke deposition and retention in airways is valuable in its own right, an important use of these data is to improve models of smoke deposition and retention in humans. This extrapolation from laboratory animal models to humans employs mathematical models of the deposition and clearance mechanisms. These models exist but are parameterized with adjustable parameters that are approximated. The deposition and retention measurements will assist modelers in extrapolating laboratory animal model results to humans. The incumbent will work with colleagues with expertise in modeling smoke deposition and retention to translate the laboratory animal model data to a form that improves the models for human exposure.
- Publication of Results. The results of the measurement and modeling studies need to be published in the peer-reviewed literature so that investigators in the field are aware of the most up-to-date results. The incumbent will work on papers reporting these results in collaboration with other on the research team.
- PhD in biological sciences with an emphasis in anatomy, physiology, and/or toxicology.
- Extensive research experience in inhalation toxicology and cardiopulmonary biology.
- Extensive knowledge and experience in aerosol research, specifically methods and measures relating to aerosol generation and characterization.
- Extensive experience with methods and measures relating to rodent models of inhalation exposure.
- Extensive experience with tissue microdissection, histology, imaging techniques, specifically fluorescent microscopy and hyperspectral imaging systems.
- Proven knowledge and experience with dosimetric modeling and quantitative chromatography, specifically ICP/MS and LC-MS.
To apply to the position please use the link: https://recruit.ucdavis.edu/JPF05102
The search will be open from 8/15/2022 - 9/1/2022